CMLD-2, CAS [[958843-91-9]]

Product Overview

• Article Name: CMLD-2, CAS [[958843-91-9]]
• Biozol Catalog Number: TGM-T36493
• Supplier Catalog Number: T36493
• Alternative Catalog Number: TGM-T36493-1MLX10MM(INDMSO),TGM-T36493-1MG,TGM-T36493-5MG,TGM-T36493-10MG,TGM-T36493-25MG,TGM-T36493-50MG,TGM-T36493-100MG,TGM-T36493-500MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor effects through MAD2 downregulation. CMLD-2 (1-75 µM , 24-72 h) had an inhibitory effect on the viability of thyroid cancer cells.CMLD-2 (20-30 µM , 24-48 h) activated caspases and induced apoptosis in H1299 and A549 cells.CMLD-2 (30 µM , 24-48 h) induced G1 cell cycle arrest in H1299 and A549 cells and mitochondrial perturbation. CMLD-2 (30 µM , 24-48 h) reduced the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.CMLD-2 (35 µM , 72 h) decreased the directional migration ability of SW1736, 8505C, BCPAP and K1 cells.CMLD-2 induced the migration of SW1736, 8505C, BCPAP and K1 cells with a strong decrease in MAD2 mRNA levels.

Product Properties

• Molecular Weight: 513.58
• Purity: 99.16%
• CAS Number: [958843-91-9]
• Formula: C31H31NO6
• Target: Apoptosis|||HuR

Images

T36493