DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor of MtDHFR, with an IC50 of 7 µM. The enzyme dihydrofolate reductase from M. tuberculosis (MtDHFR) holds high unexploited potential as a drug target due to its importance for pathogen survival. DHFR-IN-2 can be used for tuberculosis (TB) research [1].
Molekulargewicht:
227.26
CAS Nummer:
[331942-46-2]
Formel:
C14H13NO2
Target-Kategorie:
Others|||Antifolate
T60286
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