AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor with an IC50 of 12.12 µM. It blocks TNF-alpha-induced necroptosis with an EC50 of 1.7 µM, but not apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart, and kidney, inflammatory diseases, neurodegenerative diseases, and infectious diseases [1].
Molekulargewicht:
234.25
CAS Nummer:
[233605-81-7]
Formel:
C11H14N4O2
Target-Kategorie:
Others|||RIP kinase
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
