AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor with an IC50 of 12.12 µM. It blocks TNF-alpha-induced necroptosis with an EC50 of 1.7 µM, but not apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart, and kidney, inflammatory diseases, neurodegenerative diseases, and infectious diseases [1].
Molecular Weight:
234.25
CAS Number:
[233605-81-7]
Formula:
C11H14N4O2
Target:
Others|||RIP kinase
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