NITD-916, a 4-hydroxy-2-pyridone derivative, is a mycobacterial enoyl reductase InhA inhibitor (IC50=570 nM) with oral activity and high lipophilicity. Capable of forming a ternary complex with InhA and NADH, blocking fatty acyl substrate binding and inhibiting mycolic acid synthesis, thereby exerting potent anti-tuberculosis effects.
Molekulargewicht:
311.42
Reinheit:
98.98%
CAS Nummer:
[1614262-83-7]
Formel:
C20H25NO2
Target-Kategorie:
Antibacterial|||Antibiotic
T60774
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