NITD-916 is an orally active and highly lipophilic inhibitor of Mycobacterium enoyl reductase InhA with an IC50 of 570 nM.NITD-916 is a potent 4-hydroxy-2-pyridone derivative that forms a ternary complex with InhA and NADH, preventing access to the fatty acyl substrate-binding pocket.NITD-916 exhibits antituberculosis activity.
Molekulargewicht:
311.42
Reinheit:
99.78%
CAS Nummer:
[1614262-83-7]
Formel:
C20H25NO2
Target-Kategorie:
Antibacterial|||Antibiotic
T60774
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