TPBM is a potent inhibitor of estrogen receptor alpha (ERalpha). The IC 50 value of TPBM for 17beta-estradiol (E2)-ERalpha is 9 µM. TPBM is not toxic to cells and reduces E2ERalpha recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERalpha-positive cancer cells with an IC 50 value of 5 µM. TPBM does not affect estrogen-independent cell growth [1].
Molekulargewicht:
316.38
CAS Nummer:
[6466-43-9]
Formel:
C15H16N4O2S
Target-Kategorie:
Estrogen Receptor/ERR|||Others
T60827
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