TPBM is a potent estrogen receptor alpha (ERalpha) inhibitor with an IC50 value of 9 µM for disruption of 17beta-estradiol-ERalpha interaction, effectively reducing E2ERalpha recruitment to endogenous estrogen-responsive genes and inhibiting E2-dependent proliferation of ERalpha-positive cancer cells with an IC50 of 5 µM, while remaining non-toxic and not affecting estrogen-independent cell growth, making it a selective probe for ERalpha signaling research.
Molecular Weight:
316.38
Purity:
99.64%
CAS Number:
[6466-43-9]
Formula:
C15H16N4O2S
Target:
Estrogen Receptor/ERR
T60827
T60827
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