PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of peripheral blood mononuclear cells in co-cultures with PD-L1 expressing cancer cells (PC9 and HCC827 cells). It significantly elevated the release of interferon gamma and induced apoptosis in cancer cells, while exhibiting minimal cytotoxicity in healthy cells [1].
Molekulargewicht:
377.44
Formel:
C21H23N5O2
Target-Kategorie:
Others|||PD-1/PD-L1|||Apoptosis
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
