PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of peripheral blood mononuclear cells in co-cultures with PD-L1 expressing cancer cells (PC9 and HCC827 cells). It significantly elevated the release of interferon gamma and induced apoptosis in cancer cells, while exhibiting minimal cytotoxicity in healthy cells [1].
Molecular Weight:
377.44
Formula:
C21H23N5O2
Target:
Others|||PD-1/PD-L1|||Apoptosis
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