TGFbeta-IN-2 (Compound 9d) effectively inhibits TGF-beta-induced accumulation of total collagen in NRK-49F cells, with an IC50 value of 4.31 µM. It also suppresses the TGF-beta-induced in vitro expression of COL1A1, alpha-SMA, and p-Smad3. Additionally, TGFbeta-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].
Molekulargewicht:
378.42
CAS Nummer:
[2387678-02-4]
Formel:
C22H22N2O4
Target-Kategorie:
Others|||TGF-beta/Smad
T61586
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