TGFbeta-IN-2 (Compound 9d) effectively inhibits TGF-beta-induced accumulation of total collagen in NRK-49F cells, with an IC50 value of 4.31 µM. It also suppresses the TGF-beta-induced in vitro expression of COL1A1, alpha-SMA, and p-Smad3. Additionally, TGFbeta-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].
Molecular Weight:
378.42
CAS Number:
[2387678-02-4]
Formula:
C22H22N2O4
Target:
Others|||TGF-beta/Smad
T61586
* VAT and and shipping costs not included. Errors and price changes excepted