Dyrk1A-IN-5 (compound 5j) is a highly potent and selective DYRK1A inhibitor with an IC50 of 6 nM, reducing the phosphorylation of Thr434 in SF3B1 dose-dependently (IC50 = 0.5 µM) and inhibiting tau phosphorylation at Thr212 (IC50 = 2.1 µM), making it valuable for Down syndrome research [1].
Molekulargewicht:
388.16
CAS Nummer:
[1685235-41-9]
Formel:
C16H9IN2O2
Target-Kategorie:
DYRK|||Others
T61739
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
