Dyrk1A-IN-5 (compound 5j) is a highly potent and selective DYRK1A inhibitor with an IC50 of 6 nM, reducing the phosphorylation of Thr434 in SF3B1 dose-dependently (IC50 = 0.5 µM) and inhibiting tau phosphorylation at Thr212 (IC50 = 2.1 µM), making it valuable for Down syndrome research [1].
Molecular Weight:
388.16
CAS Number:
[1685235-41-9]
Formula:
C16H9IN2O2
Target:
DYRK|||Others
T61739
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