SR12418 is a specific synthetic ligand for REV-ERB, demonstrating binding affinity for both REV-ERBalpha (IC50 = 68 nM) and REV-ERBbeta (IC50 = 119 nM) in TR-FRET assays. SR12418 inhibits IL-17A expression in EL4 cells and suppresses TH17 cell differentiation, making it suitable for studies on experimental autoimmune encephalomyelitis (EAE) and colitis.
Molekulargewicht:
483.57
Reinheit:
99.96%
CAS Nummer:
[1801185-08-9]
Formel:
C31H30FNO3
Target-Kategorie:
Autophagy|||IL Receptor|||REV-ERB
T63206
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
