SR12418 is a specific synthetic ligand for REV-ERB, demonstrating binding affinity for both REV-ERBalpha (IC50 = 68 nM) and REV-ERBbeta (IC50 = 119 nM) in TR-FRET assays. SR12418 inhibits IL-17A expression in EL4 cells and suppresses TH17 cell differentiation, making it suitable for studies on experimental autoimmune encephalomyelitis (EAE) and colitis.
Molecular Weight:
483.57
Purity:
99.96%
CAS Number:
[1801185-08-9]
Formula:
C31H30FNO3
Target:
Autophagy|||IL Receptor|||REV-ERB
T63206
* VAT and and shipping costs not included. Errors and price changes excepted
