LPA5 antagonist 1 is a highly potent and selective antagonist of lysophosphatidic acid receptor 5 (LPA5), with an IC50 value of 32 nM. LPA5 antagonist 1 is a small molecule with high brain permeability that significantly alleviates mechanical allodynia in a CFA-induced inflammatory pain model and can be used to study the mechanisms underlying inflammatory and neuropathic pain. LPA5 antagonist 1 is a click chemistry reagent containing an alkyne functional group, capable of undergoing a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with molecules bearing an azide group.
Molekulargewicht:
486.58
Reinheit:
98.63%
CAS Nummer:
[2839471-45-1]
Formel:
C28H26N2O4S
Target-Kategorie:
LPA Receptor
T63231
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