AZD0780 (EX-A6975, PCSK9-IN-12) is an orally active PCSK9 inhibitor with high affinity for PCSK9 (Kd < 200 nM). It binds to a specific pocket in the C-terminal domain of PCSK9 without affecting the PCSK9-LDLR interaction. AZD0780 blocks the lysosomal trafficking of the PCSK9-LDLR complex and prevents PCSK9-induced LDLR degradation, making it useful for studies related to hypercholesterolemia.
Molekulargewicht:
414.41
Reinheit:
99.74%
CAS Nummer:
[2455427-91-3]
Formel:
C20H20F2N6O2
Target-Kategorie:
Others
T64362
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