NSC697923, CAS [[343351-67-7]]

Produktübersicht

• Artikelname: NSC697923, CAS [[343351-67-7]]
• Artikelnummer: TGM-T6611
• Hersteller Artikelnummer: T6611
• Alternativnummer: TGM-T6611-1MLX10MM(INDMSO),TGM-T6611-5MG,TGM-T6611-10MG,TGM-T6611-25MG,TGM-T6611-50MG,TGM-T6611-100MG,TGM-T6611-500MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

Produktbeschreibung

NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-kappaB signaling, further contributing to its antitumor activity.

Produkteigenschaften

• Molekulargewicht: 267.26
• Reinheit: 97.00%
• CAS Nummer: [343351-67-7]
• Formel: C11H9NO5S
• Target-Kategorie: E1/E2/E3 Enzyme|||Apoptosis

Bilder

T6611