NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-kappaB signaling, further contributing to its antitumor activity.
Molecular Weight:
267.26
Purity:
97.00%
CAS Number:
[343351-67-7]
Formula:
C11H9NO5S
Target:
E1/E2/E3 Enzyme|||Apoptosis
T6611
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