BMS-903452 is a potent and selective GPR119 agonist with an EC50 of 14 nM, indicated for the treatment of acute and chronic rodent diabetes. GPR119 is mainly expressed in pancreatic b cells and gastrointestinal endocrine cells. BMS-903452 shows no significant inhibitory effect on 9 cytochrome P450 enzymes (IC50 > 40 µM), does not activate PXR (EC50 > 50 µM), and is not toxic to liver (HEPG2) cell lines.
Molekulargewicht:
513.37
Reinheit:
>99.99%
CAS Nummer:
[1339944-47-6]
Formel:
C21H19Cl2FN4O4S
Target-Kategorie:
GPCR
T67791
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten