BMS-903452 is a potent and selective GPR119 agonist with an EC50 of 14 nM, indicated for the treatment of acute and chronic rodent diabetes. GPR119 is mainly expressed in pancreatic b cells and gastrointestinal endocrine cells. BMS-903452 shows no significant inhibitory effect on 9 cytochrome P450 enzymes (IC50 > 40 µM), does not activate PXR (EC50 > 50 µM), and is not toxic to liver (HEPG2) cell lines.
Molecular Weight:
513.37
Purity:
>99.99%
CAS Number:
[1339944-47-6]
Formula:
C21H19Cl2FN4O4S
Target:
GPCR
T67791
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