Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.
Molekulargewicht:
348.35
CAS Nummer:
[801-52-5]
Formel:
C16H20N4O5
Target-Kategorie:
Others|||DNA Alkylator/Crosslinker
T68675
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