PD-321852, CAS [[622856-21-7]]

Produktübersicht

• Artikelname: PD-321852, CAS [[622856-21-7]]
• Artikelnummer: TGM-T68981
• Hersteller Artikelnummer: T68981
• Alternativnummer: TGM-T68981-25MG,TGM-T68981-50MG,TGM-T68981-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A, in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines.

Produkteigenschaften

• Molekulargewicht: 468.33
• CAS Nummer: [622856-21-7]
• Formel: C24H19Cl2N3O3
• Target-Kategorie: Others

Bilder

T68981