PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A, in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines.
Molecular Weight:
468.33
CAS Number:
[622856-21-7]
Formula:
C24H19Cl2N3O3
Target:
Others
T68981
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