Pipendoxifene, CAS [[198480-55-6]] Preis auf Anfrage

Produktübersicht

• Artikelname: Pipendoxifene, CAS [[198480-55-6]] Preis auf Anfrage
• Artikelnummer: TGM-T70013
• Hersteller Artikelnummer: T70013
• Alternativnummer: TGM-T70013-25MG,TGM-T70013-50MG,TGM-T70013-100MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50 = 14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50 = 0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923 . In preclinical models, ERA-923 has an improved efficacy and safety compared with tamoxifen. In the combination with temsirolimus, ERA-923 showed excellent anticancer activity in preclinical models.

Produkteigenschaften

• Molekulargewicht: 456.58
• CAS Nummer: [198480-55-6]
• Formel: C29H32N2O3
• Target-Kategorie: Estrogen Receptor/ERR|||Others

Bilder

T70013