Pipendoxifene, CAS [[198480-55-6]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T70013
Supplier Catalog Number:
T70013
Alternative Catalog Number:
TGM-T70013-25MG,TGM-T70013-50MG,TGM-T70013-100MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50 = 14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50 = 0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923 . In preclinical models, ERA-923 has an improved efficacy and safety compared with tamoxifen. In the combination with temsirolimus, ERA-923 showed excellent anticancer activity in preclinical models.
Molecular Weight:
456.58
CAS Number:
[198480-55-6]
Formula:
C29H32N2O3
Target:
Estrogen Receptor/ERR|||Others
T70013
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