Theliatinib (Xiliertinib) tartrate is a potent and highly selective EGFR inhibitor with ATP-competitive and orally active properties, showing a K_i of 0.05 nM and an IC_50 of 3 nM for EGFR, and an IC_50 of 22 nM for the EGFR T790M/L858R mutant, with over 50-fold selectivity for EGFR compared to other kinases.
Molekulargewicht:
592.6
CAS Nummer:
[2413487-72-4]
Formel:
C29H32N6O8
Target-Kategorie:
EGFR|||Others
T72431
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