Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kdelta and casein kinase-1-epsilon (CK1epsilon), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 µM for PI3Kdelta and CK1epsilon respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies.
Molekulargewicht:
743.75
CAS Nummer:
[1532533-72-4]
Formel:
C38H32F3N5O6S
Target-Kategorie:
PI3K|||Casein Kinase|||Others
T72465
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