HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a \( K_d \) value of 35.7 µM. It induces CDK4/6 degradation in B16F10 melanoma cells, arrests the cell cycle at the G0/G1 phase, and induces apoptosis. HEMTAC CDK4/6 degrader 1 can be used in cancer research [1].
Molekulargewicht:
953.49
CAS Nummer:
[2821803-61-4]
Formel:
C48H53ClN16O4
Target-Kategorie:
PROTACs|||Apoptosis|||CDK|||Others
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