JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a higher number of differentially expressed genes and increased apoptosis in HCT116 cells [1].
Molekulargewicht:
968.09
Formel:
C48H60F3N7O9S
Target-Kategorie:
Apoptosis|||PROTACs|||HDAC
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
