JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a higher number of differentially expressed genes and increased apoptosis in HCT116 cells [1].
Molecular Weight:
968.09
Formula:
C48H60F3N7O9S
Target:
Apoptosis|||PROTACs|||HDAC
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