JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a substantial increase in differentially expressed genes and augmented apoptosis in HCT116 cells [1].
Molekulargewicht:
1012.14
Formel:
C50H64F3N7O10S
Target-Kategorie:
PROTACs|||HDAC
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
