JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), particularly HDAC1/2. This activity is associated with a substantial increase in differentially expressed genes and augmented apoptosis in HCT116 cells [1].
Molecular Weight:
1012.14
Formula:
C50H64F3N7O10S
Target:
PROTACs|||HDAC
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