Tagarafdeg (CFT1946) is an orally available PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (type III) mutations, and the p61-BRAF V600E splice variant. It exhibits favourable selectivity within the proteome, including for wild-type BRAF and CRAF, and inhibits tumour cell proliferation.
Molekulargewicht:
958
Reinheit:
99.34%
CAS Nummer:
[2882165-79-7]
Formel:
C45H49F2N11O9S
Target-Kategorie:
Raf|||PROTACs
T77972
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
