Tagarafdeg (CFT1946) is an orally available PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (type III) mutations, and the p61-BRAF V600E splice variant. It exhibits favourable selectivity within the proteome, including for wild-type BRAF and CRAF, and inhibits tumour cell proliferation.
Molecular Weight:
958
Purity:
99.34%
CAS Number:
[2882165-79-7]
Formula:
C45H49F2N11O9S
Target:
Raf|||PROTACs
T77972
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