AD4 is an artemisinin-derived proteolysis targeting chimera that selectively degrades PCLAF protein with subnanomolar potency in RS4,11 leukemia cells,AD4 leads to activation of the p21/Rb signaling axis, robust anti-tumor activity, and significantly prolonged survival in RS4,11 xenograft NOD/SCID mouse models, demonstrating both in vitro and in vivo therapeutic efficacy.
Molekulargewicht:
1035.23
CAS Nummer:
[2918262-09-4]
Formel:
C55H78N4O15
Target-Kategorie:
Others|||PROTACs
T78805
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
