AD4 is an artemisinin-derived proteolysis targeting chimera that selectively degrades PCLAF protein with subnanomolar potency in RS4,11 leukemia cells,AD4 leads to activation of the p21/Rb signaling axis, robust anti-tumor activity, and significantly prolonged survival in RS4,11 xenograft NOD/SCID mouse models, demonstrating both in vitro and in vivo therapeutic efficacy.
Molecular Weight:
1035.23
CAS Number:
[2918262-09-4]
Formula:
C55H78N4O15
Target:
Others|||PROTACs
T78805
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