NDNA4 (compound 17) is a selective Hsp90alpha inhibitor (IC50: 0.34 µM) with permanent charge and low membrane permeability. It demonstrates minimal cytotoxicity against Ovcar-8 and MCF-10A cell lines (IC50 >100 µM) and maintains hERG channel maturation without triggering a heat shock response or degrading Hsp90alpha-dependent client proteins [1].
Molekulargewicht:
604.68
Formel:
C31H35F3N2O5S
Target-Kategorie:
Potassium Channel|||HSP
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
