NDNA4 (compound 17) is a selective Hsp90alpha inhibitor (IC50: 0.34 µM) with permanent charge and low membrane permeability. It demonstrates minimal cytotoxicity against Ovcar-8 and MCF-10A cell lines (IC50 >100 µM) and maintains hERG channel maturation without triggering a heat shock response or degrading Hsp90alpha-dependent client proteins [1].
Molecular Weight:
604.68
Formula:
C31H35F3N2O5S
Target:
Potassium Channel|||HSP
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