N-desmethyl Regorafenib N-oxide, CAS [[835621-12-0]]

Produktübersicht

• Artikelname: N-desmethyl Regorafenib N-oxide, CAS [[835621-12-0]]
• Artikelnummer: TGM-T84977
• Hersteller Artikelnummer: T84977
• Alternativnummer: TGM-T84977-1MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.

Produkteigenschaften

• Molekulargewicht: 484.79
• CAS Nummer: [835621-12-0]
• Formel: C20H13ClF4N4O4
• Target-Kategorie: c-Kit|||Drug Metabolite|||Others|||VEGFR|||Raf