N-desmethyl Regorafenib N-oxide, CAS [[835621-12-0]]

Product Overview

• Article Name: N-desmethyl Regorafenib N-oxide, CAS [[835621-12-0]]
• Biozol Catalog Number: TGM-T84977
• Supplier Catalog Number: T84977
• Alternative Catalog Number: TGM-T84977-1MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.

Product Properties

• Molecular Weight: 484.79
• CAS Number: [835621-12-0]
• Formula: C20H13ClF4N4O4
• Target: c-Kit|||Drug Metabolite|||Others|||VEGFR|||Raf