Z57346765 is a specific PGK1(Phosphoglycerate kinase 1) inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis. In the clinical phase, Z57346765 had a dose-dependent inhibitory effect on locally advanced renal clear cell carcinoma (KIRC) by inducing changes in the expression of genes related to cell metabolism, DNA replication, and the cell cycle.
Molekulargewicht:
294.35
Reinheit:
99.85%
CAS Nummer:
[1016340-64-9]
Formel:
C17H18N4O
Target-Kategorie:
Others|||PGK1
T87659
T87659
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