Z57346765 is a specific PGK1(Phosphoglycerate kinase 1) inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis. In the clinical phase, Z57346765 had a dose-dependent inhibitory effect on locally advanced renal clear cell carcinoma (KIRC) by inducing changes in the expression of genes related to cell metabolism, DNA replication, and the cell cycle.
Molecular Weight:
294.35
Purity:
99.85%
CAS Number:
[1016340-64-9]
Formula:
C17H18N4O
Target:
Others|||PGK1
T87659
T87659
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