RG7112D is a potent MDM2 inhibitor, effectively inhibiting MDM2-p53 and VHL-HIF1alpha interactions with IC50 values of 11 nM and >10000 nM, respectively, as determined by HTRF binding assays. It couples with VHL-Amine via an amide bond to form the bifunctional molecule YX-02-030. YX-02-030 acts as an MDM2-PROTAC, efficiently blocking MDM2-p53 binding (HTRF IC50= 63 nM). Additionally, RG7112D stabilizes MDM2 protein and enhances p53 protein levels.
Molekulargewicht:
665.65
CAS Nummer:
[2360561-90-4]
Formel:
C36H42Cl2N4O4
Target-Kategorie:
MDM-2/p53
T88196
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
