RG7112D is a potent MDM2 inhibitor, effectively inhibiting MDM2-p53 and VHL-HIF1alpha interactions with IC50 values of 11 nM and >10000 nM, respectively, as determined by HTRF binding assays. It couples with VHL-Amine via an amide bond to form the bifunctional molecule YX-02-030. YX-02-030 acts as an MDM2-PROTAC, efficiently blocking MDM2-p53 binding (HTRF IC50= 63 nM). Additionally, RG7112D stabilizes MDM2 protein and enhances p53 protein levels.
Molecular Weight:
665.65
CAS Number:
[2360561-90-4]
Formula:
C36H42Cl2N4O4
Target:
MDM-2/p53
T88196
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