Antitumor agent-172 (Compound 28) acts as an inhibitor of the beta-catenin/BCL9 interaction, featuring an IC50 of 3.92 µM. This compound exhibits high affinity for beta-catenin, with a Kd of 82 nM. Furthermore, Antitumor agent-172 activates T cells, enhances antigen presentation, and demonstrates antitumor activity along with favorable pharmacokinetic properties in murine models.
Molekulargewicht:
670.84
CAS Nummer:
[3027905-74-1]
Formel:
C37H50N8O4
Target-Kategorie:
Wnt/beta-catenin
T88629
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten