Antitumor agent-172 (Compound 28) acts as an inhibitor of the beta-catenin/BCL9 interaction, featuring an IC50 of 3.92 µM. This compound exhibits high affinity for beta-catenin, with a Kd of 82 nM. Furthermore, Antitumor agent-172 activates T cells, enhances antigen presentation, and demonstrates antitumor activity along with favorable pharmacokinetic properties in murine models.
Molecular Weight:
670.84
CAS Number:
[3027905-74-1]
Formula:
C37H50N8O4
Target:
Wnt/beta-catenin
T88629
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