TNF-alpha-IN-18, CAS [[1272322-42-5]]

Produktübersicht

• Artikelname: TNF-alpha-IN-18, CAS [[1272322-42-5]]
• Artikelnummer: TGM-T88696
• Hersteller Artikelnummer: T88696
• Alternativnummer: TGM-T88696-5MG,TGM-T88696-10MG,TGM-T88696-25MG,TGM-T88696-50MG,TGM-T88696-100MG,TGM-T88696-200MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

TNF-alpha-IN-18 (Compound 61) is a small molecule inhibitor of tumor necrosis factor-alpha (TNF-alpha) that operates with a IC50 of 1.8µM. TNF-alpha-IN-18 effectively blocks the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), thereby suppressing the downstream TNF signaling pathway, TNF-alpha-IN-18 exhibits minimal cytotoxicity in mouse fibroblast LM cells with a CC50 greater than 50 µM. TNF-alpha-IN-18has been shown to alleviate sepsis induced by TNF or lipopolysaccharide in mouse models, and provides significant protection against the development and progression of rheumatoid arthritis in murine models.

Produkteigenschaften

• Molekulargewicht: 336.67
• Reinheit: 0.9977
• CAS Nummer: [1272322-42-5]
• Formel: C16H7ClF2O4
• Target-Kategorie: NF-kappaB|||TNF

Bilder

T88696