TNF-alpha-IN-18 (Compound 61) is a small molecule inhibitor of tumor necrosis factor-alpha (TNF-alpha) that operates with a IC50 of 1.8µM. TNF-alpha-IN-18 effectively blocks the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), thereby suppressing the downstream TNF signaling pathway, TNF-alpha-IN-18 exhibits minimal cytotoxicity in mouse fibroblast LM cells with a CC50 greater than 50 µM. TNF-alpha-IN-18has been shown to alleviate sepsis induced by TNF or lipopolysaccharide in mouse models, and provides significant protection against the development and progression of rheumatoid arthritis in murine models.
Molecular Weight:
336.67
Purity:
0.9977
CAS Number:
[1272322-42-5]
Formula:
C16H7ClF2O4
Target:
NF-kappaB|||TNF
T88696
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