SMAD2 Protein, Human, Recombinant (His & SUMO)

Produktübersicht

• Artikelname: SMAD2 Protein, Human, Recombinant (His & SUMO)
• Artikelnummer: TGM-TMPH-01699
• Hersteller Artikelnummer: TMPH-01699
• Alternativnummer: TGM-TMPH-01699-1MG, TGM-TMPH-01699-5UG, TGM-TMPH-01699-10UG, TGM-TMPH-01699-20UG, TGM-TMPH-01699-50UG, TGM-TMPH-01699-100UG, TGM-TMPH-01699-200UG, TGM-TMPH-01699-500UG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: SMAD2 , MAD homolog 2 , Mothers against decapentaplegic homolog 2 , Mothers against DPP homolog 2 , Mad-related protein 2 (hMAD-2) , MADH2 , SMAD family member 2 (SMAD 2,Smad2,hSMAD2) , JV18-1 , MADR2

Produktbeschreibung

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Bilder

TMPH-01699